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Concept IDs
NCI Thesaurus
C67042
conceptId
C67042
preferredName
MDR Modulator CBT-1
description
MDR Modulator CBT-1
system_cui
nci_C67042
definition
A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors.
display_C67042
MDR Modulator CBT-1
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