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Concept IDs
NCI Thesaurus
C47764
RXNORM
220343
RXNORM
38404
conceptId
C47764
220343
38404
preferredName
Topiramate
synonym
TPM
2,3:4,5-di-O-isopropylidene-?-D-fructopyranose sulfamate
2,3:4,5-bis-O-(1-methylethylidene)-?-D-fructopyranose sulfamate
description
Topiramate-containing product
Topiramate
Topiramate (substance)
Tipiramato
Topamax
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
TOPIRAMATE
Topiramato
Tipiramate
Topiramatum
Product containing topiramate (medicinal product)
topiramate
VANDF_CUI
4021026
NDDF_CUI
005453
display_C47764
Topiramate
display_38404
Topiramate
DRUGBANK_CUI
DB00273
TTY
SU
PT
IN
GN
FN
PEP
MH
BN
FSY
ET
definition
A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
ATC_CUI
N03AX11
GS_CUI
1506
MTHSPL_CUI
0H73WJJ391
MMSL_CUI
6438
5601
162273
d04115
SNOMEDCT_US_CUI
386844006
108400009
USP_CUI
m84310
system_cui
rxnorm_220343
nci_C47764
rxnorm_38404
display_220343
Topamax
prescribable
true
MSH_CUI
D000077236
Child Concepts
Parent Concepts